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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 OR 15(d)

of The Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): November 4, 2026

CLENE INC.

(Exact name of registrant as specified in its charter)

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\n\t\t\t Delaware \n\t\t\t	\n\t\t\t 001-39834 \n\t\t\t	\n\t\t\t 85-2828339 \n\t\t\t
\n\t\t\t (State or other jurisdiction \n\t\t\t	\n\t\t\t (Commission File Number) \n\t\t\t	\n\t\t\t (IRS Employer \n\t\t\t
\n\t\t\t of incorporation) \n\t\t\t		\n\t\t\t Identification No.) \n\t\t\t

\n\t\t\t 6550 South Millrock Drive, Suite G50 \n\n\t\t\t Salt Lake City, Utah \n\t\t\t		\n\t\t\t 84121 \n\t\t\t
\n\t\t\t (Address of principal executive offices) \n\t\t\t		\n\t\t\t (Zip Code) \n\t\t\t

(801) 676-9695

(Registrant’s telephone number, including area code)

N/A

(Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

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Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

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Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

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Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

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Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

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Securities registered pursuant to Section 12(b) of the Act:

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\n\t\t\t Title of each class \n\t\t\t		\n\t\t\t Trading Symbol(s) \n\t\t\t		\n\t\t\t Name of each exchange on which registered \n\t\t\t
\n\t\t\t Common Stock, $0.0001 par value \n\t\t\t		\n\t\t\t CLNN \n\t\t\t		\n\t\t\t The Nasdaq Capital Market \n\t\t\t

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 2.02 Results of Operations and Financial Condition.

On November 4, 2026, Clene Inc. (the “Company”) issued a press release announcing its third quarter 2026 financial results and recent operating highlights for its quarter ended September 30, 2026. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference.

The information furnished in this Item 2.02, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934 (the “Exchange Act”), as amended, or otherwise subject to the liabilities of that section, and shall not be deemed to be incorporated by reference into any filing made by the Company under the Exchange Act or the Securities Act of 1933, as amended, regardless of any general incorporation language in any such filings, except as shall be expressly set forth by specific reference in such a filing.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits

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\n\t\t\t Exhibit \n\t\t\tNumber \n\t\t\t		\n\t\t\t by Exhibit Description \n\t\t\t
\n\t\t\t 99.1 \n\t\t\t		\n\t\t\t Press Release, dated November 4 2026, announcing the Company’s third quarter 2026 financial results and recent operating highlights. \n\t\t\t
\n\t\t\t 104 \n\t\t\t		\n\t\t\t Cover Page Interactive Data File (formatted as Inline XBRL). \n\t\t\t

\n1\n

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, hereunto duly authorized.

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	\n\t\t\t CLENE INC. \n\t\t\t

\n\t\t\t Date: November 4, 2026 \n\t\t\t	\n\t\t\t By: \n\t\t\t	\n\t\t\t /s/ Robert Etherington \n\t\t\t
		\n\t\t\t Robert Etherington \n\t\t\t
		\n\t\t\t President and Chief Executive Officer \n\t\t\t

\n2\n

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